Postdoctoral Research Associate | Fischer Lab
BSc. (Hons., Dunelm) Molecular Biology and Biochemistry
Durham University, St Cuthberts Society, UK (2003)
MSc. Human Reproductive Biology
Imperial College London, UK (2005)
MRC Ph.D Thesis
Genomic imprinting in human stem cells and human peripheral blood leukocytes
Imperial College London, UK (2009)
My research focusses on the molecular genetics of seed development in Arabidopsis. I am investigating the interactions between DNA methylation and transcription in the seed, and the effects of genomic imprinting on resource allocation.
Thomas AC, Frost JM, Ishida M, Vargha-Khadem F, Moore GE, Stanier P. The speech gene FOXP2 is not imprinted (2012). J Med Genet PMID: 23033221
Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, Phoolchund A, Lay K, Ramasamy TS, Cananzi M, Nettersheim D, Sullivan M, Frost J, Moore G, Vermeesch JR, Fisk NM, Thrasher AJ, Atala A, Adjaye J, Schorle H, De Coppi P, Guillot PV. Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach. Mol Ther. 2012, PMID: 22760542
Monk D, Arnaud P, Frost JM, Wood AJ, Cowley M, Martin-Trujillo A, Guillaumet-Adkins A, Iglesias Platas I, Camprubi C, Bourc’his D, Feil R, Moore GE and Oakey RJ. Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes (2011). Nucl Acids Res PMID:21300645
Frost JM, Monk D, Moschidou D, Guillot PV, Fisk NM, Minger SL, Moore HD, and Moore GE. A comparison of the effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells. Epigenetics 2011 Jan 17;6(1). (Issue front cover illustration)
Frost JM, Monk D, Stojilkovic-Mikic T, Woodfine K, Chitty LS, Murrell A, Stanier P and Moore GE. Evaluation of allelic expression of imprinted genes in adult human blood. PLoS One. 2010 Oct 21;5(10):e13556.
Frost JM, Udayashankar R, Moore HD, Moore GE. Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells. PLoS One. 2010 Jul 14;5(7):e11595
Frost JM, Moore GE. The importance of imprinting in the human placenta. PLoS Genet. 2010 Jul 1;6:e1001015
Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Hum Mol Genet. 2009 Aug 15;18(16):3066-74
Abu-Amero S, Monk D, Frost J, Preece M, Stanier P, Moore GE. The genetic aetiology of Silver-Russell syndrome. J Med Genet. 2008 Apr;45(4):193-9.
Apostolidou S, Abu-Amero S, O'Donoghue K, Frost J, Olafsdottir O, Chavele KM, Whittaker JC, Loughna P, Stanier P, Moore GE. Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. J Mol Med. 2007 Apr;85(4):379-87
Christian A. Ibarra, Jennifer M. Frost, Juhyun Shin, Tzung-Fu Hsieh, and Robert L. Fischer: Epigenetic control of Seed Gene Imprinting, pp 63-82. Seed Genomics, First Edition. Edited by Philip W Becraft, (2013) John Wiley and Sons. ISBN: 978-0-470-96015-8
Jennifer M Frost, Sayeda Abu-Amero, Caroline Daelemans and Gudrun E Moore: Epigenetics, assisted reproductive technologies and growth restriction, pp71-82 Reproductive Genetics, Edited by Sean Kehoe, Lyn Chitty and Tessa Homfray (2009) Royal College of Obstetrics and Gynaecology Press. ISBN: 978-1-906-98516-5
Medical Research Council PhD Fellowship, 2005-2009
Mammalian Developmental Genetics Workshop - Best Talk Prize, 2011