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Research Focus of PMB Scientists
Plant Disease, Disease Resistance
Professor Barbara Baker researches microbe interactions with their hosts. She is interested in the biology and chemistry behind these interactions. In particular, her lab studies how pathogens cause disease and how the host builds up disease resistance. The Baker Lab specifically studies bacterial, viral and oomycete pathogens and their plant hosts. Their research has important practical benefits and might lead to better disease-resistant crops and plants.
Computational Biology, Genomics, Protein Function Prediction
Professor Steven Brenner researches computational and experimental genomics (the study of an organism's genome). His research focuses on gene regulation, protein function and structure and personal genomics, among other things. He studies structural genomics, which aims to provide a high-quality model for every protein. In addition, he has worked with a number of collaborators to understand Crohn’s disease and how microbes in the gut can cause the disease.
Professor Tom Bruns researches the ecology and evolution of mycorrhizal fungi. Mycorrhizal fungi are fungi that form symbiotic (close and mutually beneficial) associations with plants. The fungi receive carbohydrates from the plant roots while the plant benefits from increased water absorption and mineral uptake. The Bruns Lab’s past work studied the effect of the plant host and disturbance on fungal community structure. His research group has also developed molecular tools for the identification of fungi from environmental samples.
Bioremediation, Pollution Clean-Up
Professor John Coates researches the chemical interactions between microbes and certain compounds. He studies oxidization and reduction reactions the microbes perform and the pathways behind the reactions. He uses a variety of cutting-edge molecular and chemical techniques in his research. His lab was the first to isolate a microbe that would degrade benzene, a contaminant and carcinogen that is produced in large amounts by industry.
|Adam Deutschbauer||Microbial Stress and Survival|
The Deutschbauer lab uses high-throughput genetics to address a number of outstanding questions in microbiology. Using a wealth of bacterial genetics data, we are systematically filling in unknown “gaps” in amino acid biosynthesis pathways, identifying new carbon catabolism pathways, and characterizing proteins with domains of unknown function. In parallel, we are developing new experimental strategies to streamline genetic tool development in diverse microorganisms. Lastly, we are developing a next-generation platform of chemical libraries, robotic automation, and miniaturized growth assays to enable the rapid phenotypic characterization of microorganisms and microbiomes, to greatly increase the scale of environmental microbiology research.
Plant Development, Root Development
Professor Lewis J. Feldman researches plant development, especially root development. The root cap is the site of perception for many environmental stimuli, including gravity and light. Plants have much of their physiology and biochemistry devoted to the perception and transduction of environmental stimuli. The Feldman lab investigates how the cap communicates with the rest of the root.
Plant Stem Cells, Developmental Signaling
Adjunct Professor Jennifer Fletcher studies stem cell biology in plants. Stem cell reservoirs reside at the growing tips of all plants and are the source of cells that make the leaves, stems, flowers and fruits. The transition between stem cell activity and organ formation involves complex cell signaling and gene regulation processes. The Fletcher lab uses genetic, molecular and biochemical tools to characterize these processes during plant development.
Evolutionary History of Plants
Professor Michael Freeling studies the evolutionary history of vascular plants. Vascular plants are a highly successful and diverse group of plants that have lignified tissues for carrying water and nutrients. The Freeling Lab compares the genomes of different plant lineages to infer their evolutionary relationships. The lab seeks to explain what drives evolutionary trends in vascular plants and the roles of regulatory genes and environmental stress tolerance in shaping evolution.
Professor N. Louise Glass studies how cells specialize, communicate and recognize each other. Her work is especially important for microbial organisms, which live in a complex community of cells. She seeks to understand the mechanisms that mediate cell fusion and how cells recognize each other before and after fusion. She uses the fungus Neurospora crassa as an experimental system to study these mechanisms. Her lab also focuses on how plant cell walls are degraded by fungi. This particular project has the potential to improve plant biomass degradation, which is important for the production of biofuels.
Virus-Host Interactions, RNA-Based Regulation
Professor Britt A. Glaunsinger studies how viruses manipulate gene expression in infected host cells. Glaunsinger focuses on the RNA-based regulation and viral factors that target RNA. The Glaunsinger Lab seeks to understand how viral manipulation of host cell gene expression pathways influences viral replication and disease. Her lab specifically studies gammaherpesviruses, which can cause cancers in people with weakened immune systems. Her work has also shed light on the regulation of gene expression in human cells.
Genomics of Eukaryotes, Computational Biology
Adjunct Professor Igor Grigoriev is affiliated with the US Department of Energy Joint Genome Institute. His research focuses on genomics of eukaryotes, from protists to plants. At the JGI he leads the Fungal Genomics program to explore fungal diversity, evolution and interactions.
Plant Development and Plant Architecture
Adjunct Professor Sarah C. Hake, director of the Plant Gene Expression Center, uses genetics to study plant development. Depending on the experimental question, the Hake Lab works on maize, Arabidopsis and tomato. The lab uses mutant plants that differ from normal plants to identify genes responsible for forming different parts of the plants. Once the gene is identified, the Hake Lab uses a variety of genetic and biological techniques to understand the developmental mechanisms underlying plant development.
Adjunct Associate Professor Frank G. Harmon studies circadian clocks in plants. A circadian clock is a biochemical mechanism that drives circadian rhythms, built-in biological cycles that repeat every 24 hours. Organisms use these cycles to keep time, allowing them to perform functions at the proper time. Plants use circadian rhythms to coordinate growth and respond to environmental conditions. External factors like temperature and light affect clock rhythms and therefore the plant’s response. The Harmon lab uses genetic, biochemical, molecular, and genomic approaches to study the proteins in the plant’s clock.
Professor Arash Komeili studies prokaryotic organelles. Organelles are structures in cells that have a specific function. For example, ribosomes are organelles that make proteins in cells. The Komeili Lab focuses on how organelles are produced within cells and how they are maintained. To do this, the lab uses magnetotactic bacteria, a diverse group of bacteria that can orient along magnetic fields. Their magnetic properties are due to special organelles called magnetosomes, which contain nanocrystalline magnetic compounds. Using a variety of biological and chemical tools, the lab identifies and investigates genes involved in controlling organelle formation and function.
Plant Genomics & Immunity
The Krasileva lab studies plant genomics and the interactions between plants and microbes to further food security systems and answer the question, “how do plants with innate immunity recognize new pathogens?”
Cooperative Extension Specialist Peggy Lemaux’s laboratory performs both basic and applied research focused primarily on cereal crops, like sorghum, wheat and barley. The objectives of these studies are to better understand crop plants and to use that knowledge to improve their performance and quality. Among other projects, with colleagues at UCB, Joint Genome Institute, Pacific Northwest National Laboratory and the UC Division of Agriculture and Natural Resources, her efforts focus on a DOE- funded field study to understand the mechanisms of drought tolerance in sorghum at the transcriptional and epigenetic level, including its microbiome. Also Lemaux develops various educational resources on food and agriculture, including an award-winning website, http://ucbiotech.org, middle school curricula, educational displays, games and videos, for the media, teachers and consumers. Lemaux leads the CLEAR (Clear, Literacy & Education for Agricultural Research) group of departmental graduate and undergraduate students and postdocs, who are developing ways to better communicate with the public on contemporary issues in science.
Plant Disease and Immunity
Adjunct Associate Professor Jennifer D. Lewis studies the interaction between plants and the bacterial pathogen Pseudomonas syringae, and downstream host defense responses. Pathogen-encoded virulence proteins are excellent tools to probe immune signaling pathways in plants. The Lewis Lab’s work will lead to a greater understanding of plant immunity and will help devise strategies to protect plants from disease.
Ecology of Plant-Associated Microorganisms
Professor Steven Lindow studies the interactions that occur between bacteria and fungi and the plants on which they live. Most of his research emphasize the study of various bacteria, including plant pathogenic and ice nucleation active species that live on the surfaces of plants as epiphytes. The Lindow lab also uses molecular approaches to study the traits that bacteria utilize to colonize the stressful habitat of plant surfaces. His work also addresses cell density-dependent expression of genes by quorum sensing in these bacteria as well as those that colonize the vascular system of plants. In addition, molecular ecological approaches are being used to study the effects of endophytic alkaloid-producing fungi on the bacterial communities on plants.
Plant Responses to the Environment
Professor Sheng Luan researches how plants respond and adapt to their environment. Unlike most animals, plants are immobile and cannot move when conditions become unfavorable. Therefore, plants have evolved complex mechanisms to perceive and respond to environmental change. The Luan Lab studies the molecular mechanisms and biochemical pathways behind these mechanisms. Some of his research deals with metabolic regulation in chloroplast and environmental sensing in plants.
Pollen, Plant Fertilization;
Adjunct Professor Emerita Sheila McCormick researched plant reproduction. The McCormick Lab studied pollen-specific receptor kinases in pollen tubes and how the receptor kinases send and receive signals so that pollen tubes can grow towards the ovule (female structure). They also studied pollen development and function by using mutants. Lastly, they were interested in the molecular mechanisms underlying double fertilization in plants.
Algal and environmental genomics, chloroplast metabolism, photosynthesis, metalloproteins
The Merchant group has discovered mechanisms used by photosynthetic organisms to optimize performance in face of changing metal supply, especially limitation. Reduce, reuse and recycle! For instance, the Cu quota is dramatically reduced (to less than 5% relative to a Cu replete situation) by replacement of the copper-protein plastocyanin in photosynthesis with a functionally equivalent heme-containing cytochrome.
Biofuels, Algae, Photosynthesis
Professor Anastasios Melis studies the photosynthesis in plants, microalgae,cyanobacteria and photosynthetic bacteria. The Melis Lab pioneered the concept of “photosynthetic biofuels,” the direct production of biofuels from photosynthesis. The lab was the first to discover that depriving algae of sulfur caused it to produce hydrogen instead of oxygen. Numerous advances in biofuel development have been made by the Melis Lab.
Regulation of Photosynthesis
Professor Krishna K. Niyogi studies algae and plants to understand how photosynthetic energy conversion works, how it is regulated, and how it might be improved to help meet the world's needs for food and fuel. By comparing how photosynthesis works in diverse organisms, he hopes to uncover general design principles of natural photosynthesis as well as unique adaptations to different environments.
Microbial Disease, Defending Against Infection
Professor of Biochemistry and Molecular Biology Daniel Portnoy is an associate of the department. The Portnoy Lab studies the molecular and cellular basis behind microbial pathogenesis (how a disease is caused) and the mechanisms the host uses to defend against infection. The lab focuses on the bacterium Listeria monocytogenes, which can evade its mammalian host’s immune system with its unique moving mechanism.
Light Signaling in Plants, Solar Energy Capture Optimization
Professor Peter Quail researches the molecular mechanisms behind how light regulates gene expression in plants. The lab focuses on phytochromes, a family of photoreceptor that acts as a shape change when light is detected, then triggers a DNA transcription response. The Quail Lab has developed a light-switchable gene promoter that will allow for condition induction or repression of the plant light response.
Bacterial Cell Cycle, Regulatory Pathways
Associate Professor Kathleen Ryan researches Caulobacter crescentus, a rod-shaped bacterium, and its life cycle. Her research group looks into genes responsible for the complex mechanisms Caulobacter carries out. She has studied how they control cell division and why their cell division is asymmetric (uneven, producing two unequal cells).
Renewable Energy, Plant Cell Walls
Adjunct Professor Henrik Vibe Scheller works at the Joint BioEnergy Institute in Emeryville. The Scheller Lab investigates complex polysaccharides and glycoproteins in the plant cell wall, using Arabidopsis and rice as model plants. Polysaccharides and glycoproteins are the main components of cell walls and thus of the biomass. Their research has important significance for the development of better crop plants suited for biofuel production.
Plant-pathogen interactions; mechanisms of host defense; cell wall integrity sensing
Professor Shauna Somerville studies the interaction between plants and their pathogens and the role the plant plays in disease development. Her lab works with powdery mildew disease on the model plant Arabidopsis thaliana. They use mutants to identify factors in the plant host necessary for disease development. Her lab also studies non-host resistance, a mechanism that protects all members of a plant species from all members of a pathogen species, a new area of plant-pathogen interactions.
Professor Brian Staskawicz studies plant immunity against disease. His lab elucidates the molecular basis of this immunity from the perspective of both the pathogen and the plant host. His findings and cutting-edge methods have answered many questions in this field. The Staskawicz lab has also started studying molecular plant pathology to engineer durable resistance in crop species, which can increase crop production.
Plant Growth and Development
Professor Emerita Renee Sung studied the development and growth of plants. She researched how plants regulate their development and control cell differentiation (when a cell becomes specialized into a more specific cell type). One of the questions she tried to answer is, “What controls cell growth in plants?” She focused on how changes in the activity of a flowering gene affect shoot development in Arabidopsis.
Microbial Interactions, Cofactor Synthesis
Associate Professor Michi Taga researches how microbes share nutrients. Microbes, like any other living organisms, live in complex communities that contain many species. The Taga Lab researches how microbes synthesize and exchange small molecules. In particular, the lab researches a class of compounds called corrinoids, which includes Vitamin B12.
Phytoremediation, Cleanup of Environmental Pollutants
Professor Emeritus Norman Terry used constructed wetlands to clean up wastewater contaminated with agricultural and industrial pollutants. HIs research on phytoremediation, using plants to clean up the environment, was multidisciplinary and ranged from the molecular to the field level. His lab was one of the first in the world to demonstrate the use of transgenic plants to remove contaminants from soil under field conditions.
Bacterial Interactions and Metabolism
Assistant Professor Matt Traxler explores the chemical ecology of interactions between actinomycete bacteria. His research program incorporates whole-genome transcriptomics and newly developed mass spectrometry techniques to examine the physiology of actinomycete interactions as they relate to natural product biosynthesis, and translates these insights into a new platform for natural products discovery.
Associate Professor Mary Wildermuth studies the interactions between plants and microbes. Plants, like humans, are continuously exposed to disease-causing microbes -- 14% of crops worldwide are lost to microbial disease each year. Conversely, there are also good microbes that can increase crop production. By understanding the complex interactions between plants and microbes, the Wildermuth Lab can predict how these interactions may change in response to altered environmental conditions. Wildermuth seeks to maintain the productivity of crops by augmenting the plant’s own responses. In addition, her basic research on phytohormones and plant disease resistance has led to implications for human innate immunity.
|Ben Williams||Plant Epigenetics and Cell Identity|
The Williams lab is interested in understanding how epigenetic information is inherited over many cell divisions and generations. Plants are composed of many types of cells, each of which contains the same DNA. Epigenetic information adds a layer of complexity, as it is dynamic and can be modified in different cells. Understanding how this works will help us understand how the genome is organized, how certain genes are switched on and off, and how different cell types are defined. The Williams lab is particularly interested in epigenetic information that is consistently inherited for very long periods of time.
Genetic Engineering and Cell-Cell Connections
Professor Emerita Patricia Zambryski did research in both microbial biology and plant biology. In microbial biology, she researched how Agrobacterium, a genus of Gram-negative bacteria, transfers DNA to plants. Because of this unique transformation ability, Agrobacterium has been used for genetic engineering. Professor Zambryski also studied how plant cells communicate with each other through unique plant-specific intercellular structures called plasmodesmata.