Antonio Pedro Da Rocha Cardoso Goncalves

Postdoctoral fellow | Glass Lab

Glass Lab - Cell-cell communication and fusion

341 Koshland Hall

Berkeley, California 94720-3102

2014: PhD (Molecular Pathology and Genetics), Abel Salazar Biomedical Sciences Institute of the University of Porto, Portugal.

2008: Bachelor degree, School of Allied Health Sciences of the Polytechnic Institute of Porto, Portugal.

Research

The ability to form a hyphal network is a hallmark of filamentous fungi. In filamentous ascomycete species such as Neurospora crassa, an individual hypha (a multinucleate, multicellular filament with incomplete crosswalls) grows by hyphal tip extension and branching. Behind the growing colony margin, fusions between hyphae are continuously formed, yielding a network of interconnected hyphae, which make up the fungal individual. Although the capacity to form a network is ubiquitous in filamentous fungi, little is known about how they form and function. Our studies have revealed a complex and carefully regulated biological process.

List of publications

Gonçalves AP, Cordeiro JM, Monteiro J, Lucchi C, Correia-de-Sá P, Videira A. Involvement of mitochondrial proteins in calcium signaling and cell death induced by staurosporine in Neurospora crassa. Biochim Biophys Acta-Bioenergetics 2015;1847(10):1064-74.

Palma-Guerrero J, Zhao J, Gonçalves AP, Starr TL, Glass NL. Identification and characterization of LFD-2, a predicted Fringe protein required for membrane integrity during cell fusion in Neurospora crassa. Eukaryot Cell 2015;14(3):265-77.

Gonçalves AP, Videira A. Mitochondrial type II NAD(P)H dehydrogenases in fungal cell death. Microbial Cell 2015;2(3):68-73.

Gonçalves AP, Silva N, Oliveira C, Kowbel DJ, Glass NL, Kijjoa A, Palmeira A, Sousa E, Pinto M, Videira A. Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone. Genom Data 2015;4:26-32.

Gonçalves AP, Monteiro J, Lucchi C, Kowbel DJ, Cordeiro JM, Correia-de-Sá P, Rigden DJ, Glass NL, Videira A. Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa. Microbial Cell 2014;1(9):289-302.

Gonçalves AP, Cordeiro JM, Monteiro J, Muñoz A, Correia-de-Sá P, Read ND, Videira A. Activation of a TRP-like channel and intracellular calcium dynamics during phospholipase C-mediated cell death. J Cell Sci 2014;127(Pt 17):3817-29.

Gonçalves AP, Hall C, Kowbel DJ, Glass NL, Videira A. CZT-1 is a novel transcription factor controlling cell death and natural drug resistance in Neurospora crassa. G3 (Bethesda) 2014;4(6):1091-102.

Gonçalves AP, Videira A. Programmed cell death in Neurospora crassa. New J Sci 2014; 2014, Article ID 479015.

Fernandes AS, Gonçalves AP, Castro A, Lopes TA, Gardner R, Glass NL, Videira A. Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling. Fungal Genet Biol 2011;48(12):1130-8.

Gonçalves AP, Videira A, Maximo V, Soares P. Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. J Biosci 2011;36(4):639-48.

Gonçalves AP, Videira A, Soares P, Máximo V. Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR. Life Sci 2011;89(11-12):371-7.

Gonçalves AP, Máximo V, Lima J, Singh KK, Soares P, Videira A. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta-Mol Cell Res 2011;1813(3):492-9.

Other activities and awards

2015: Member of The Millet Project team (http://themilletproject.org/)

2013: Awarded with a student fellowship to present an oral communication at the “PYFF5 - 5th Conference on Physiology of Yeast and Filamentous Fungi”, in Montpellier, France.

2012: Awarded with an individual EMBO Short-term fellowship.

2009: PhD research fellowship from Fundação Calouste Gulbenkian.

apgoncalves@berkeley.edu

Phone:

510.643.2546

Pedro

Gonçalves

Glass

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