W. Zacheus Cande
The Cande Lab researched the mechanism of chromosome segregation during mitosis and meiosis, to understand changes in chromosome structure and behavior that lead to pairing of homologous chromosomes during meiotic prophase and their segregation at Meiosis I and II. The lab used three model organisms: Giardia intestinalis, Schizosaccharomyces pombe, and Zea mays. The lab also used a computerized light microscope workstation that recorded three-dimensional images of multiple cellular components in fixed and living cells.
Andrew O. Jackson
The Jackson Lab research focused on how viruses elicit plant diseases, and devised mechanisms for disease control in transgenic plants, working with three viruses: a plus sense monopartite RNA virus, tomato bushy stunt virus; a plus sense tripartite RNA virus, barley stripe mosaic virus; and a minus strand plant rhabdovirus, sonchus yellow net virus. The lab used genetic and biochemical analysis to investigate replication and movement of these viruses and to determine virus-host interactions culminating in disease.
Watson M. Laetsch
Watson Laetch grows walnuts commercially, raises antique apple varieties and has a vineyard producing Chardonnay and Merlot grapes, from which he makes wine. He serves on the CNR Advisory Board, is Co-Chair of Bancroft Library Capital Campaign and Mark Twain Lunch Club and also is involved in Friends of Cal History, and leads Bear Treks with his wife. He's the past and present Chair, Board of Directors, Children's Hospital Oakland Research Institute; Member, Board of Directors, Children's Hospital and Research Center at Oakland; and Member, Board of Trustees, University of California Press Foundation.
Most of the proteins involved in photosynthetic energy conversion and electron transport seem organized into integral membrane protein complexes. Dick Malkin studied the structure-function relationships of the cytochrome b6f complex, an essential electron transfer complex that links the two photosystems in all oxygenic photosynthetic organisms.
The Theologis Lab researched the molecular mechanism of auxin action, using auxin-inducible genes as probes. The Lab isolated novel, interacting proteins that bind to the auxin responsive domains, and constructed Arabidopsis transgenic lines for isolating mutants responsible for transcriptional activation by auxin. They also researched ACC synthase gene expression regulation. The Lab used some ACS genes as molecular probes to study signal transduction pathways responsible for auxin inducibility of ACC synthase gene expression.
After 27 years studying baculovirus pathogenesis, Loy Volkman retired from Cal in January, 2007. Her work showed that baculoviruses uniquely usurp the actin cytoskeleton for progeny production. In 2006, her lab and that of Matthew Welch demonstrated that the interaction of viral protein Ac p78/83 and the cellular Arp2/3 complex regulates nuclear actin in baculovirus-infected cells (Science 314,464-468, 06). Volkman continues to participate in baculovirus research as a Welch lab guest member at UC Berkeley, and as an Expression Systems advisory board member in Woodland, CA.
The Zusman Lab did research to determine how signal transduction regulates directed motility and behavior in the bacterium Myxococcus xanthus using an integrated approach that combines biochemistry, genetics, cell biology, and molecular biology. M. xanthus is an excellent model system to address fundamental questions concerning cell-cell signaling and directed movement as cells form multicellular biofilms and fruiting bodies as part of a complex life cycle.